Add to ORKGproteins to be orthologous only if they are mutual best matches by BLAST and map to regions of conserved synteny, as determined by DNA sequen-ceÐbased anchors (see text), between the mouse and human genomes. In addition, we include in our analysis only the class of paralogs that are the result of local gene duplication in one or the other species. We are aware that this is a narrow view of these concepts but use it here for the sake of clarity
Despite the common assumption that orthologs usually share the same function, there have been variou...
In comparative genomic studies, syntenic groups of homologous sequence in the same order have been u...
A key complication in comparative genomics for reliable gene function prediction is the existence of...
<div><p>The function of most proteins is not determined experimentally, but is extrapolated from hom...
The function of most proteins is not determined experimentally, but is extrapolated from homologs. A...
<div><p>The ortholog conjecture posits that orthologous genes are functionally more similar than par...
A recent paper (Nehrt et al., PLoS Comput. Biol. 7:e1002073, 2011) has proposed a metric for the fu...
The function of most proteins is not determined experimentally, but is extrapolated from homologs. A...
<p>In all but one of these experiments, the yeast gene was mutated and the gene from the other organ...
Lacking experimental data, protein function is often predicted from evolutionary and protein structu...
<p>Italic font indicates classes of genes that are covered by SyntenyMapper. Internal orthologs: Ort...
Thanks to the improvement of genome sequencing technology, abundant multi-species genomic data now b...
The recent introduction of biochemical and molecular methods for characterizing and mapping genes ha...
Mammalian cellular systems are composed of diverse molecular components (e.g. genes, transcripts and...
The massive advancements in genomics over recent years has not only provided scope to examine what i...
Despite the common assumption that orthologs usually share the same function, there have been variou...
In comparative genomic studies, syntenic groups of homologous sequence in the same order have been u...
A key complication in comparative genomics for reliable gene function prediction is the existence of...
<div><p>The function of most proteins is not determined experimentally, but is extrapolated from hom...
The function of most proteins is not determined experimentally, but is extrapolated from homologs. A...
<div><p>The ortholog conjecture posits that orthologous genes are functionally more similar than par...
A recent paper (Nehrt et al., PLoS Comput. Biol. 7:e1002073, 2011) has proposed a metric for the fu...
The function of most proteins is not determined experimentally, but is extrapolated from homologs. A...
<p>In all but one of these experiments, the yeast gene was mutated and the gene from the other organ...
Lacking experimental data, protein function is often predicted from evolutionary and protein structu...
<p>Italic font indicates classes of genes that are covered by SyntenyMapper. Internal orthologs: Ort...
Thanks to the improvement of genome sequencing technology, abundant multi-species genomic data now b...
The recent introduction of biochemical and molecular methods for characterizing and mapping genes ha...
Mammalian cellular systems are composed of diverse molecular components (e.g. genes, transcripts and...
The massive advancements in genomics over recent years has not only provided scope to examine what i...
Despite the common assumption that orthologs usually share the same function, there have been variou...
In comparative genomic studies, syntenic groups of homologous sequence in the same order have been u...
A key complication in comparative genomics for reliable gene function prediction is the existence of...