Metformin, a widely used anti-diabetic agent of the biguanide family, although generally safe,1,2,3,4 holds the risk of developing a potentially lethal acidosis.5,6 The association between lactic acidosis and met-formin is well-established but rarely seen in patients taking this medication.7 Its elimination relies solely on kidneys ’ excretion,8 so its accumulation is feas-ible in just two circumstances: renal failure (RF) and acute overdosage. At normal dosage, a toxic accumulation of drug requires time after the development of RF, due to metformin high clearance. About 90 % of the drug is eliminated by glomerular filtration and tubular se-cretion (serum half-life of 1.5–5 h). Moreover, RF i
Metformin is an oral antidiabetic drug in the biguanide class, which is used for type 2 diabetes. Th...
Metformin is recommended as a first-line treatment for patients with diabetes mellitus type 2; it ha...
Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic...
Metformin, a widely used anti-diabetic agent of the biguanide family, although generally safe holds ...
Metformin is commonly used in the treatment of type 2 diabetes mellitus (DM). Severe lactic acidosis...
Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lac...
Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lac...
WOS: 000493544800012PubMed ID: 31673464Metformin is an oral antidiabetic medication which belongs to...
ABSTRACT: A case of fatal intoxication from metformin is presented. The decedent was an obese 58-yea...
The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations c...
A case of fatal intoxication from metformin is presented. The decedent was an obese 58-year-old-woma...
Metformin is an oral antidiabetic agent from the group of biguanide compounds. Metformin-related lac...
Metformin is a biguanide used in the treatment of type 2 diabetic patients with normal renal functio...
A 43-year-old woman was brought to the hospital with severe metabolic acidosis (pH 6.56, bicarbonate...
Metformin is an oral antidiabetic drug in the biguanide class, which is used for type 2 diabetes. Th...
Metformin is an oral antidiabetic drug in the biguanide class, which is used for type 2 diabetes. Th...
Metformin is recommended as a first-line treatment for patients with diabetes mellitus type 2; it ha...
Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic...
Metformin, a widely used anti-diabetic agent of the biguanide family, although generally safe holds ...
Metformin is commonly used in the treatment of type 2 diabetes mellitus (DM). Severe lactic acidosis...
Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lac...
Metformin is an oral antihyperglycemic agent used in the management of type 2 diabetes mellitus. Lac...
WOS: 000493544800012PubMed ID: 31673464Metformin is an oral antidiabetic medication which belongs to...
ABSTRACT: A case of fatal intoxication from metformin is presented. The decedent was an obese 58-yea...
The elimination of metformin is exclusively through the kidneys and elevated plasma concentrations c...
A case of fatal intoxication from metformin is presented. The decedent was an obese 58-year-old-woma...
Metformin is an oral antidiabetic agent from the group of biguanide compounds. Metformin-related lac...
Metformin is a biguanide used in the treatment of type 2 diabetic patients with normal renal functio...
A 43-year-old woman was brought to the hospital with severe metabolic acidosis (pH 6.56, bicarbonate...
Metformin is an oral antidiabetic drug in the biguanide class, which is used for type 2 diabetes. Th...
Metformin is an oral antidiabetic drug in the biguanide class, which is used for type 2 diabetes. Th...
Metformin is recommended as a first-line treatment for patients with diabetes mellitus type 2; it ha...
Metformin intoxication with lactic acidosis, a potentially lethal condition, may develop in diabetic...