Role of Lymph nodes in adjuvant-induced arthritis in rats

The arthritic syndrome induced in rats by an intradermal injection of a fine suspension of dead mycobacteria in liquid paraffin was first described by Stoerk, Bielinski, and Budzilovich (1954) and later studied in detail by Pearson (1956, 1959). The syn-drome is characterized by the appearance of inflamed lesions, called secondary lesions, remote from the injection site after a delay of approximately 10 days. The mechanisms involved in the development of secondary lesions are still obscure. There is little evidence to support the idea that an infectious agent is involved (Sharp, Waksman, Pearson, and Madoff, 1961), although Jones and Ward (1963), from their histological studies, consider that this is still a possibility. It is also unlikely that an auto-immun