Bio-Medical Computing (2) (1971)- @ Elsevier Publishing Company Ltd, England-Printed in Great Britain

This paper, which is being presented in two parts, is concerned with the problem of a realistic and useful simulation of a living cell, the simple unicellular bacterium Escherichia coli, the program being written in Fortran IVfor an IBM 360167 computer. The object is to represent the cell in such a way as to simulate its growth in real environments of a living cell, as well as during changes from one chemical environ-ment to another. This simulation could also supply useful information for answering current questions in biology. In Part 2 of this paper the authors describe the method of evolving DNA and discuss cancer in relation to the computer simulation under consideration. Literature references cited in both parts of the paper, as well as the appendix to the work, are also presented. SOMMAIRE Cette etude s’occupe du probleme dune simulation realiste et utile dune cellule vivante: la bacterie simple et unicellulaire Escherichia coli, le programme &ant ecrit en Fortran IV pour un ordinateur IBM 360/G. Le but c’est de representer la cellule de telle fagon h simuler la croissance de celle-ci dans le milieu veritable dune celhde vivante ainsi que pendant les changements d’un milieu chimique a un autre. Cette simtdation pourrait aussi fournir des renseignements utiles en repondant h des questions courantes dans la biologie