CLINICAL TRIALS AND OBSERVATIONS

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group

Brugières, Laurence
Le Deley, Marie-Cécile
Rosolen, Angelo
Williams, Denise
Horibe, Keizo
Wrobel, Grazyna
Mann, Georg
Zsiros, Jozsef
Uyttebroeck, Anne
Marky, Ildiko
Lamant, Laurence
Reiter, Alfred

January 2009

Purpose To compare the efficacy and safety of two methotrexate doses and administration schedules in...

CLINICAL TRIALS AND OBSERVATIONS Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children’s Oncology Group (POG 9404)

Steven E. Lipshultz
Bruce M. Camitta

September 2016

phase 3 trial 9404 was designed to deter-mine the effectiveness of high-dose methotrexate (HDM) when...

High dose methotrexate in the treatment of children with acute lymphoblastic leukemia

Johannes Bondan Lukito

February 2007

Background It has been claimed that around 70% of childhood acute lymphoblastic leukemia (ALL) can b...

High-dose methotrexate vs. Capizzi methotrexate for the treatment of childhood T-cell acute lymphoblastic leukemia

Wasil Jastaniah
Naglla Elimam
Khalid Abdalla
Aeshah A. AlAzmi
Mohammed Aseeri
Sami Felimban

January 2018

Sixty-three children (1–14 years of age) newly diagnosed with T-cell acute lymphoblastic leukemia we...

Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

Jönsson, Peter

January 2008

Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it w...

Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia

Csordas, Katalin
Hegyi, Márta
Eipel, Olivér
Müller, Judit
Erdélyi, Dániel
Kovács, Gábor

November 2015

We carried out a detailed comparative study of the pharmacokinetics and toxicity of methotrexate (MT...

High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: Lack of relation between serum methotrexate concentration and creatinine clearance

Joannon, Pilar
Oviedo, Iris
Campbell, Myriam
Tordecilla, Juan

January 2004

Background. The objectives of this study were: (1) to analyze the relation of serum methotrexate (MT...

Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: a ten-year follow-up

Freeman, Arnold I.
Boyett, James M.
Glicksman, Arvin S.
Brecher, Martin L.
Leventhal, Brigid G.
Sinks, Lucius F.
Holland, James F.

February 1997

The cure rate of childhood acute lymphoblastic leukemia (ALL) has improved dramatically. Still there...

Accumulation of Methotrexate Polyglutamates in Lymphoblasts Is a Determinant of Antileukemic Effects In Vivo A Rationale for High-Dose Methotrexate

J. Clin Invest
Eric Masson
Mary V. Relling
Timothy W. Synold
Qing Liu
John D. Schuetz
John T. S
Ching-hon Pui
William E. Evans
After Hdmtx

September 2016

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphob...

Benefits Of The Intermittent Use Of 6-mercaptopurine And Methotrexate In Maintenance Treatment For Low-risk Acute Lymphoblastic Leukemia In Children: Randomized Trial From The Brazilian Childhood Cooperative Group--protocol All-99.

Brandalise, Silvia R
Pinheiro, Vitória R
Aguiar, Simone S
Matsuda, Eduardo I
Otubo, Rosemary
Yunes, José A
Pereira, Waldir V
Carvalho, Eny G
Cristofani, Lilian M
Souza, Marcelo S
Lee, Maria L
Dobbin, Jane A
Pombo-de-Oliveira, Maria S
Lopes, Luiz F
Melnikoff, Katharina N T
Brunetto, Algemir L
Tone, Luiz G
Scrideli, Carlos A
Morais, Vera L L
Viana, Marcos B

November 2015

PURPOSE To describe event-free survival (EFS) and toxicities in children with low-risk acute lymphob...

Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group

BRUGIERES L
LE DELEY MC
WILLIAMS D
HORIBE K
WROBEL G
MANN G
ZSIROS J
UYTTEBROECK A
MARKY I
LAMANT L
REITER A.
ROSOLEN, ANGELO

January 2009

Purpose To compare the efficacy and safety of two methotrexate doses and administration schedules in...

High Dose Methotrexate in Treatment of Acute Lymphoblastic Leukemia: Toxicity Profile and Comparison of Tolerability Between Two Dosage Schedules.

Arun, Warrier

February 2009

INTRODUCTION: The rate of success in the treatment of acute lymphoblastic leukemia (ALL) has incre...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group

Brugières, Laurence
Le Deley, Marie-Cécile
Rosolen, Angelo
Williams, Denise
Horibe, Keizo
Wrobel, Grazyna
Mann, Georg
Zsiros, Jozsef
Uyttebroeck, Anne
Marky, Ildiko
Lamant, Laurence
Reiter, Alfred

January 2009

Purpose To compare the efficacy and safety of two methotrexate doses and administration schedules in...

CLINICAL TRIALS AND OBSERVATIONS Effectiveness of high-dose methotrexate in T-cell lymphoblastic leukemia and advanced-stage lymphoblastic lymphoma: a randomized study by the Children’s Oncology Group (POG 9404)

Steven E. Lipshultz
Bruce M. Camitta

September 2016

phase 3 trial 9404 was designed to deter-mine the effectiveness of high-dose methotrexate (HDM) when...

High dose methotrexate in the treatment of children with acute lymphoblastic leukemia

Johannes Bondan Lukito

February 2007

Background It has been claimed that around 70% of childhood acute lymphoblastic leukemia (ALL) can b...

High-dose methotrexate vs. Capizzi methotrexate for the treatment of childhood T-cell acute lymphoblastic leukemia

Wasil Jastaniah
Naglla Elimam
Khalid Abdalla
Aeshah A. AlAzmi
Mohammed Aseeri
Sami Felimban

January 2018

Sixty-three children (1–14 years of age) newly diagnosed with T-cell acute lymphoblastic leukemia we...

Aspects on optimisation of High Dose Methotrexate treatment in children with Acute Lymphoblastic Leukaemia

Jönsson, Peter

January 2008

Childhood Acute Lymphoblastic Leukaemia (ALL) has a unique place in the history of oncology, as it w...

Comparison of pharmacokinetics and toxicity after high-dose methotrexate treatments in children with acute lymphoblastic leukemia

Csordas, Katalin
Hegyi, Márta
Eipel, Olivér
Müller, Judit
Erdélyi, Dániel
Kovács, Gábor

November 2015

We carried out a detailed comparative study of the pharmacokinetics and toxicity of methotrexate (MT...

High-dose methotrexate therapy of childhood acute lymphoblastic leukemia: Lack of relation between serum methotrexate concentration and creatinine clearance

Joannon, Pilar
Oviedo, Iris
Campbell, Myriam
Tordecilla, Juan

January 2004

Background. The objectives of this study were: (1) to analyze the relation of serum methotrexate (MT...

Intermediate-dose methotrexate versus cranial irradiation in childhood acute lymphoblastic leukemia: a ten-year follow-up

Freeman, Arnold I.
Boyett, James M.
Glicksman, Arvin S.
Brecher, Martin L.
Leventhal, Brigid G.
Sinks, Lucius F.
Holland, James F.

February 1997

The cure rate of childhood acute lymphoblastic leukemia (ALL) has improved dramatically. Still there...

Accumulation of Methotrexate Polyglutamates in Lymphoblasts Is a Determinant of Antileukemic Effects In Vivo A Rationale for High-Dose Methotrexate

J. Clin Invest
Eric Masson
Mary V. Relling
Timothy W. Synold
Qing Liu
John D. Schuetz
John T. S
Ching-hon Pui
William E. Evans
After Hdmtx

September 2016

Methotrexate (MTX) is one of the most widely used drugs for the treatment of childhood acute lymphob...

Benefits Of The Intermittent Use Of 6-mercaptopurine And Methotrexate In Maintenance Treatment For Low-risk Acute Lymphoblastic Leukemia In Children: Randomized Trial From The Brazilian Childhood Cooperative Group--protocol All-99.

Brandalise, Silvia R
Pinheiro, Vitória R
Aguiar, Simone S
Matsuda, Eduardo I
Otubo, Rosemary
Yunes, José A
Pereira, Waldir V
Carvalho, Eny G
Cristofani, Lilian M
Souza, Marcelo S
Lee, Maria L
Dobbin, Jane A
Pombo-de-Oliveira, Maria S
Lopes, Luiz F
Melnikoff, Katharina N T
Brunetto, Algemir L
Tone, Luiz G
Scrideli, Carlos A
Morais, Vera L L
Viana, Marcos B

November 2015

PURPOSE To describe event-free survival (EFS) and toxicities in children with low-risk acute lymphob...

Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group

BRUGIERES L
LE DELEY MC
WILLIAMS D
HORIBE K
WROBEL G
MANN G
ZSIROS J
UYTTEBROECK A
MARKY I
LAMANT L
REITER A.
ROSOLEN, ANGELO

January 2009

Purpose To compare the efficacy and safety of two methotrexate doses and administration schedules in...

High Dose Methotrexate in Treatment of Acute Lymphoblastic Leukemia: Toxicity Profile and Comparison of Tolerability Between Two Dosage Schedules.

Arun, Warrier

February 2009

INTRODUCTION: The rate of success in the treatment of acute lymphoblastic leukemia (ALL) has incre...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Age and high-dose methotrexate are associated to clinical acute encephalopathy in FRALLE 93 trial for acute lymphoblastic leukemia in children.

Dufourg, M. N.
Landman-Parker, J.
Auclerc, M. F.
Schmitt, C.
Perel, Y.
Michel, G.
Levy, P.
Couillault, G.
Gandemer, V.
Tabone, M. D.
Demeocq, F.
Vannier, J. P.
Leblanc, T.
Leverger, G.
Baruchel, A.

February 2007

International audienceThe objective of the study was to assess acute neurotoxicity associated with t...

Impact of the Methotrexate Administration Dose on the Need for Intrathecal Treatment in Children and Adolescents With Anaplastic Large-Cell Lymphoma: Results of a Randomized Trial of the EICNHL Group

Brugières, Laurence
Le Deley, Marie-Cécile
Rosolen, Angelo
Williams, Denise
Horibe, Keizo
Wrobel, Grazyna
Mann, Georg
Zsiros, Jozsef
Uyttebroeck, Anne
Marky, Ildiko
Lamant, Laurence
Reiter, Alfred

January 2009

Purpose To compare the efficacy and safety of two methotrexate doses and administration schedules in...

CLINICAL TRIALS AND OBSERVATIONS

Abstract

Extracted data

CLINICAL TRIALS AND OBSERVATIONS

Abstract

Extracted data

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