PERSPECTIVES A Looser Clock to Cure Jet Lag PHYSIOLOGY

A neuropeptide that signals in the brain’s master circadian clock may be the key to overcoming the symptoms of malaise associated with jet lag. J et lag is a blessing to circadian biologists because the disruption of mental and physical well-being immediately high-lights the importance of our internal “body clock. ” It is also a curse because jet lag has so far eluded attempts at a cure. On page 85 of this issue, Yamaguchi et al. ( 1) show that mice lacking receptors for the neuropeptide arginine vasopressin (AVP) are resistant to jet lag, providing new hope of overcomin