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tumours were predominantly adrenal predominantly extra-adrenal in location and associated with higher catecholamine secretion and Introduction Amar et al. 2005). Phaeochromocytomas are tumours arising from catecholamine-producing chromaffin cells Endocrine-Related Cancer (2009) 16 515–525(VHL), RET, succinate dehydrogense-B (SDHB),Recent studies have shown that w25 % of apparently sporadic phaeochromocytomas and paragangliomas are due to germ line mutations in one of severa