CORRESPONDENCE Re: Prediction of Carboplatin Clearance From Standard Morphological and Biological Patient Characteristics

(2) recently discussed methods for mea-suring serum creatinine in relation to in-dividualized dosing of carboplatin. However, they did not note that the Cockcroft–Gault-estimated creatinine clearance (3) should not be used as the glomerular filtration rate (GFR) when an enzymatic method such as the per-oxidase–antiperoxidase (PAP) method is used to measure creatinine. The Cock-croft–Gault equation estimates creati-nine clearance, not GFR. Because creat-inine is both filtered by glomeruli and secreted by renal tubules, creatinine clearance exceeds GFR. Among meth