Myocardial Flow Reserve Partially Recovered after Additional Intensive Anti- Hyperglycemic Therapy in Patients with Type 2 Diabetes

Background: Hyperglycemia has been suggested as a significant factor in coronary microangiopathy in patients with type 2 diabetes (T2DM), but whether it can be reversed through treatment of hyperglycemia is still unknown. Aim: To clarify whether glycemic control can improve coronary microangiopathy in T2DM. Methods: Subjects were 34 T2DM patients who underwent coronary angiography and 17 age-matched controls. Myocardial segments perfused by angiographically normal coronary arteries were studied. Baseline myocardial blood flow (MBF, ml/min/100 g) and MBF during dipyridamole administration (0.56 mg/kg/ min) were measured using positron emission tomography (PET). Myocardial flow reserve (MFR) was calculated by the ratio of MBF during dipyridamole administration to the baseline MBF. Afte