Consulting Physician, The Hospital for Tropical Diseases, London, N. W. I Hyperinfection in Malignant Tertian Infection

Where there is hyperinfection associated with cerebral features, where algid malaria is found, where the patient cannot swallow or when vomiting and diarrhoea are severe, anti-malaria drugs should be given intravenously. For this purpose, quinine hydrochloride gr. I0 in I0 to 20 ml. of isotonic saline may be slowly injected at the rate of i gr. per minute and repeated in six hours if necessary. The injection must be given slowly owing to the severe drop of blood pressure resulting from rapid injection. Never more than three injections should be given in the first 24 hours. If the blood pressure is unduly low or algid symptoms are present, quinine hydro-chloride may be given slowly in one pint of salin