POSTER PRESENTATION Open Access Doxorubicin leads to impaired insulin signaling in skeletal muscle

Doxorubicin is an antibiotic largely used in clinical prac-tice for the treatment of several types of tumors. However, its application may be limited by triggering some host’s deleterious effects, such as extreme fatigue, anorexia, sar-copenia, cardiovascular diseases, among others [1]. The role of skeletal muscle in this process should be further elucidated as this tissue is still important for glucose homeostasis [2] and becomes impaired by doxorubicin treatment. Knowledge of doxorubicin’s effect in the skele-tal muscle and in the mechanism of action involved on the systemic insulin sensitivity is still incipient. The aim of this study is to evaluate the mechanism of insulin resistance after doxorubicin treatment. Materials and methods Wistar rats received a single dose of intraperitonea