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Pressure-driven membrane filtration processes such as microfiltration (MF), ultrafiltration (UF), nanofiltration (NF), and reverse osmosis (RO) provide opportunities for the dairy industry to better utilize milk by separating its components based on size. However, widespread adoption of some of these processes has yet to be realized due to membrane fouling. Membrane fouling is the accumulation of soil, or foulant, on the surface or within the pores of a membrane. Fouling prolongs processing times, increases energy and cleaning costs, decreases separation efficiency, and, in severe cases, may lead to irreversible clogging of the membrane. Microfiltration can be used to remove serum proteins (SP) from skim milk. The process’ SP removal efficiency directly influences the technology’s financial feasibility. Our first objective was to quantify the capacity of 0.14 µm ceramic Isoflux MF membranes to remove SP from skim milk. The Isoflux membranes ’ manufacturer claims that using these membranes will reduce localized membrane fouling at the inlet end of the membrane that results from using high cross-flow velocities (5 – 7 m/s) to mitigate overall membrane fouling. Contrary to theoretical cumulative SP removal percentages of 68%, 90%, and 97 % after 1, 2, and 3 stages of 3X M