Sterically Stabilized Hydrogel Nanoparticles: in Vitro Evaluation as a Novel Carrier for Water-Insoluble Drugs

Suspensions composed of numberless nanoparticles were used for improved solubilization of phenylpropanolamine (PPA). Nanoparticles encapsulating PPA HCl were prepared using the solid jelly pulverization technique. The size of the PPA HCl- hydrogel nanoparticles was assessed using a LS particle size analyzer and scanning electron microscopy (SEM). The rheological properties of suspensions are characterized by Cone and Plate Viscometer. In addition, any drug-polymer interactions were assessed using a differential scanning calorimeter (DSC). The results show that solid jelly pulverization technique yielded PPA HCl hydrogel nanoparticles with a mean diameter of 40 nm to 800 nm. Based on our release profiles, following an initial burst release of 40 % to 50 % PPA HCl, the release was sustained over the 24-hours study period. Moreover, while pH value of PPA HCl- loaded nanoparticles suspension increased over 3, no significant agglomeration of insoluble drug were grown. The DSC measurements indicated that the chemical interaction does not occur among the components during manufacturing processes and reconstituting lyophilized powder. The above results will be helpful to possible development of the other water-insoluble drug delivery systems