To identify potential involvement of tumor suppressor gene inactivation during leukemogenesis by Moloney murine leukemia virus (M-MuLV), a genome-wide scan for loss of heterozygosity (LOH) in tumor DNAs was made. To assess LOH, it is best to study mice that are heterozygous at many loci across the genome. Accord-ingly, we generated a collection of 52 M-MULV-induced tumor DNAs from C57BR/cdJ 3 AKR/J F1 (BRAKF1) hybrid mice. By using direct hybridization with oligonucleotides specific for three different classes of endoge-nous MuLV-related proviruses, 48 markers on 16 of 19 autosomes were simultaneously examined for allelic loss. No allelic losses were detected, with the exception of a common loss of markers on chromosome 4 in two tumors. The...
Little is understood about the basic biological mechanisms that underlie the reasons for acute trans...
We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H...
Highly rearranged and mutated cancer genomes present major challenges in the identification of patho...
Loss of heterozygosity (LOH) occurs commonly in some human tumors and is thought to reflect the sele...
Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes...
AbstractBreast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and spor...
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several mega...
Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic los...
Alterations in oncogenes and tumor suppressor genes (TSGs) are considered to be critical steps in on...
Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma ...
Loss of heterozygosity (LOH) is detectable in many forms of cancer including leukaemia. It contribut...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
<div><p>Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/l...
The cyclin dependent kinase (CDK) inhibitors p15, p16, p21, and p27 are frequently deleted, silenced...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
Little is understood about the basic biological mechanisms that underlie the reasons for acute trans...
We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H...
Highly rearranged and mutated cancer genomes present major challenges in the identification of patho...
Loss of heterozygosity (LOH) occurs commonly in some human tumors and is thought to reflect the sele...
Loss of heterozygosity (LOH) occurs commonly in cancers causing disruption of tumor suppressor genes...
AbstractBreast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and spor...
Loss of heterozygosity (LOH) is a common genetic alteration in tumors and often extends several mega...
Breast tumors in (FVB × BALB-NeuT) F1 mice have characteristic loss of chromosome 4 and sporadic los...
Alterations in oncogenes and tumor suppressor genes (TSGs) are considered to be critical steps in on...
Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/lymphoma ...
Loss of heterozygosity (LOH) is detectable in many forms of cancer including leukaemia. It contribut...
Loss of heterozygosity (LOH) is a common genetic event in cancer development, and is known to be inv...
<div><p>Here we report the isolation of a murine model for heritable T cell lymphoblastic leukemia/l...
The cyclin dependent kinase (CDK) inhibitors p15, p16, p21, and p27 are frequently deleted, silenced...
The analysis of loss of heterozygosity (LOH) in tumours can be used to map candidate sites of tumour...
Little is understood about the basic biological mechanisms that underlie the reasons for acute trans...
We generated allelotypes of 38 methylene chloride-induced lung carcinomas from female C57BL/6J x C3H...
Highly rearranged and mutated cancer genomes present major challenges in the identification of patho...