Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial diseases. We recently completed its genome sequence and found it contains a large number of gene clusters putatively responsible for the biosynthesis of nonribosomal peptides and polyketides, including the previously identified antifungal dihydromaltophilin (HSAF). One of the gene clusters contains two huge open reading frames, together encoding 12 modules of nonribosomal peptide synthetases (NRPS). Gene disruption of one of the NRPS led to the disappearance of a metabolite produced in the wild type and the elimination of its antibacterial activity. The metabolite and antibacterial activity were also affected by the disruption of some of the f...
The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and seque...
The rise of multidrug resistant bacteria and the gap in antibiotics development pose a serious threa...
Streptomyces is the largest antibiotic-producing genus in the microbial world. Manumycin-type antibi...
Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial d...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
The discovery of new antibiotics is one of the most urgent tasks facing scientists today. The escala...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
Lantibiotics are antimicrobial peptides that have been the focus of much attention in recent years w...
Most of the known antibiotics still in use nowadays have been discovered in the 1940s–1960s by exten...
WAP-8294A is a group of cyclic lipodepsipeptides and considered as the first-in-class new chemical e...
WAP-8294A is a family of at least 20 cyclic lipodepsipeptides exhibiting potent anti-MRSA activity. ...
In search for antifungal compounds with novel chemistry and a new mode of action, we isolated a heat...
This thesis presents regulatory and biosynthetic mechanisms by which microorganisms produce secondar...
Antibiotic A201A produced by Saccharothrix mutabilis subsp. capreolus NRRL3817 contains an aminonucl...
The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and seque...
The rise of multidrug resistant bacteria and the gap in antibiotics development pose a serious threa...
Streptomyces is the largest antibiotic-producing genus in the microbial world. Manumycin-type antibi...
Lysobactor enzymogenes strain OH11 is an emerging biological control agent of fungal and bacterial d...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
The discovery of new antibiotics is one of the most urgent tasks facing scientists today. The escala...
Bioactive natural products are a major source of anti-infectives. Many ubiquitous inhabitants of soi...
Lantibiotics are antimicrobial peptides that have been the focus of much attention in recent years w...
Most of the known antibiotics still in use nowadays have been discovered in the 1940s–1960s by exten...
WAP-8294A is a group of cyclic lipodepsipeptides and considered as the first-in-class new chemical e...
WAP-8294A is a family of at least 20 cyclic lipodepsipeptides exhibiting potent anti-MRSA activity. ...
In search for antifungal compounds with novel chemistry and a new mode of action, we isolated a heat...
This thesis presents regulatory and biosynthetic mechanisms by which microorganisms produce secondar...
Antibiotic A201A produced by Saccharothrix mutabilis subsp. capreolus NRRL3817 contains an aminonucl...
The biosynthetic gene cluster for the 17 aa peptide antibiotic enduracidin has been cloned and seque...
The rise of multidrug resistant bacteria and the gap in antibiotics development pose a serious threa...
Streptomyces is the largest antibiotic-producing genus in the microbial world. Manumycin-type antibi...