Reverse transcription of the hepadnavirus genome initiates near the 3 ' end of the RNA template and has previously been shown to depend on sequences flanking the initiation site for DNA synthesis (C. Seeger and J. Maragos, J. Virol. 64:16-23, 1990). DNA synthesis leads to the covalent attachment of a protein to the 5 ' end of minus-strand DNA, and it is generally believed that this protein serves as the primer for reverse transcription. To examine priming in more detail, we have carried out a detailed genetic analysis of the nucleotide sequences at the origin of minus-strand DNA synthesis characterized in our earlier study. This mutational analysis has led to the identification of a short, four-nucleotide-long sequence as the sign...
Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein...
The early DNA products of reverse transcr ipt ion have been analyzed from reconstructed reactions co...
The viral polymerase and several cis-acting sequences are essential for hepadnaviral DNA replication...
Replication of the hepadnavirus genome occurs by reverse transcription of an RNA pregenome and is me...
Although an overall genetic strategy for hepadnaviral reverse transcription has been established, th...
AbstractAlthough an overall genetic strategy for hepadnaviral reverse transcription has been establi...
The synthesis of the hepadnavirus relaxed circular DNA genome requires two template switches, primer...
To study the replication strategy of the human hepatitis B virus, the 5' end of the RNA pregenom...
A characteristic of all hepadnaviruses is the relaxed-circular conformation of the DNA genome within...
Hepadnaviruses are DNA viruses that are found in several mammalian and avian species. These viruses ...
Duck hepatitis B virus (DHBV) is a DNA virus that replicates via reverse transcription of a pregenom...
Hepadnavirus polymerases initiate reverse transcription in a protein-primed reaction that involves t...
<div><p>Replication of hepatitis B virus (HBV) via protein-primed reverse transcription is initiated...
AbstractThe primer binding site (PBS) is involved in two stages during the reverse transcription of ...
Hepadnaviruses, with the human hepatitis B virus as prototype, are small, enveloped hepatotropic DNA...
Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein...
The early DNA products of reverse transcr ipt ion have been analyzed from reconstructed reactions co...
The viral polymerase and several cis-acting sequences are essential for hepadnaviral DNA replication...
Replication of the hepadnavirus genome occurs by reverse transcription of an RNA pregenome and is me...
Although an overall genetic strategy for hepadnaviral reverse transcription has been established, th...
AbstractAlthough an overall genetic strategy for hepadnaviral reverse transcription has been establi...
The synthesis of the hepadnavirus relaxed circular DNA genome requires two template switches, primer...
To study the replication strategy of the human hepatitis B virus, the 5' end of the RNA pregenom...
A characteristic of all hepadnaviruses is the relaxed-circular conformation of the DNA genome within...
Hepadnaviruses are DNA viruses that are found in several mammalian and avian species. These viruses ...
Duck hepatitis B virus (DHBV) is a DNA virus that replicates via reverse transcription of a pregenom...
Hepadnavirus polymerases initiate reverse transcription in a protein-primed reaction that involves t...
<div><p>Replication of hepatitis B virus (HBV) via protein-primed reverse transcription is initiated...
AbstractThe primer binding site (PBS) is involved in two stages during the reverse transcription of ...
Hepadnaviruses, with the human hepatitis B virus as prototype, are small, enveloped hepatotropic DNA...
Hepadnaviruses, including human hepatitis B virus (HBV), replicate their tiny DNA genomes by protein...
The early DNA products of reverse transcr ipt ion have been analyzed from reconstructed reactions co...
The viral polymerase and several cis-acting sequences are essential for hepadnaviral DNA replication...