Key Words. Sarcoma • Soft tissue • Pediatric malignancy • Chemotherapy • Ewing’s sarcoma • Synovial sarcoma Disclosures

Section editors Laurence Baker and Jaap Verweij have disclosed no financial relationships relevant to the content of this article. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. LEARNING OBJECTIVES After completing this course, the reader will be able to: 1. Describe the heterogeneous histologies of soft tissue sarcomas that may occur in pediatric and young adult patients. 2. Explain biology, risk classification, prognosis, and rational clinical management of pediatric type and adult type soft tissue sarcomas. 3. Discuss the ways in which the histology and stage of cancer are currently used to devise treatment plans and how monitoring subsets (such as subtype of sarcoma, adequacy of resection, age of patient, and duration of therapy) and trying novel agents may improve results in pediatric STS. This article is available for continuing medical education credit at CME.TheOncologist.com.CM