Neuroendocrine tumors of the pancreas

Section editors Herbert Chen and Stan B. Sidhu have disclosed no financial relationships relevant to the content of this article. The content of this article has been reviewed by independent peer reviewers to ensure that it is balanced, objective, and free from commercial bias. LEARNING OBJECTIVES 1. Assess the basic aspects of PNET tumor biology, pathogenesis, and classification. 2. Explain the epidemiology and evaluate the prognosis of PNET patients. 3. Engage in rational clinical management of PNETs. This article is available for continuing medical education credit at CME.TheOncologist.com.CME This literature review briefly summarizes the epidemi-ology, pathophysiology, clinical management, and out-comes of patients with pancreatic neuroendocrine tumors (PNETs) and highlights recent advances in PNET research. PNETs are rare neoplasms, compared with carcinomas arising from pancreatic exocrine tis