7XUJXWg]DO7ÕS0HUNH]L'HUJLVL 34 Nedocromil Sodium Worsens Ozone-Induced Lung Function Changes in Healthy Non-Smoking Subjects

Ozone exposure can result in acute reversible restrictive and obstructive lung functions changes. The mechanism for these changes may be related to release of neuropeptides from sensory nerve endings in the airway. Nedocromil sodium may act by inhibiting neuropeptide release and thus could possibly prevent ozone-induced decrements in lung function. Four responders (non-smoking volunteers with>15 % decline in FEV1 to ozone exposure) and 5 non-responders (<5 % decline in FEV1 to ozone) were exposed to 30 minutes of exercise in 0.25-0.30 ppm ozone after receiving 2 days of nedocromil sodium with the last dose immediately before O3 exposure. In both the responders and non-responders, pre-treatment with nedocromil sodium subsequent ozone exposure resulted in greater decreases in FEV1 and FVC than with ozone exposure alone (p<0.05). Nedocromil sodium which is thought to work in part by inhibiting release of neuropeptides from airway sensory nerve endings worsened O3- induced pulmonary function changes in nonsmoking volunteers. [Journal of Turgut Özal Medical Center 1998;5(1):34-39