Phenotypic and Epidemiologic Correlates of Auxotype in Neisseria gonorrhoeae

which require arginine, hypoxanthine, and uracil (Arg"Hyx-Ura- auxotype) are uniformly highly susceptible to penicillin G, are relatively resistant to complement-dependent killing by heated, pooled human serum, and are associated with dissem-inated gonococcal infection. For further study of the epidemiology of these strains and for analysis of the susceptibility to penicillin, serum sensitivity, and the nutri-tional requirements of gonococcal isolates from other cities, a survey was made of urethral and cervical strains isolated in 1972-1974 from 50 randomly selected patients with uncomplicated gonorrhea from each of nine cities. Arg-Hyx"Ura- strains repre