Add to ORKGMore than 30 missense mutations in the b-cardiac myosin heavy chain gene have been shown to be responsible for fa-milial hypertrophic cardiomyopathy. To clarify the effects of these point mutations on myosin motor function, we ex-pressed wild-type and mutant human b-cardiac myosin heavy chains in insect cells with human cardiac light chains. The wild-type myosin was well purified with similar enzy-matic and motor activities to those of the naturally isolated V3 cardiac myosin. Ar
Hypertrophic cardiomyopathy occurs as an autosomal domi-nant familial disorder or as a sporadic dise...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
More than 30 missense mutations in the beta-cardiac myosin heavy chain gene have been shown to be re...
Several mutations in distinct genes, all coding for sarcomeric proteins, have been reported in unrel...
Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in 9 sarcomeric protein genes. The...
Several mutations in distinct genes, all coding for sarcomeric proteins, have been reported in unrel...
Abstract: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high i...
Force generation and the ability of the heart muscle to contract and correspondingly to beat depends...
AbstractWe have studied the actin-activated ATPase activities of three mutations in the motor domain...
Familial Hypertrophic Cardiomyopathy (FHC) is frequently caused by mutations in the β-cardiac myosin...
Abstract—Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in 9 sarcomeric protein g...
Uncovering the genetic bases for cardiac disease has been a central focus of biomedical research for...
Background\u2014Mutations in the -myosin heavy-chain (MyHC) gene cause hypertrophic (HCM) and dilate...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
Hypertrophic cardiomyopathy occurs as an autosomal domi-nant familial disorder or as a sporadic dise...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
More than 30 missense mutations in the beta-cardiac myosin heavy chain gene have been shown to be re...
Several mutations in distinct genes, all coding for sarcomeric proteins, have been reported in unrel...
Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in 9 sarcomeric protein genes. The...
Several mutations in distinct genes, all coding for sarcomeric proteins, have been reported in unrel...
Abstract: Hypertrophic (HCM) and dilated (DCM) cardiomyopathies are inherited diseases with a high i...
Force generation and the ability of the heart muscle to contract and correspondingly to beat depends...
AbstractWe have studied the actin-activated ATPase activities of three mutations in the motor domain...
Familial Hypertrophic Cardiomyopathy (FHC) is frequently caused by mutations in the β-cardiac myosin...
Abstract—Familial hypertrophic cardiomyopathy (HCM) is caused by mutations in 9 sarcomeric protein g...
Uncovering the genetic bases for cardiac disease has been a central focus of biomedical research for...
Background\u2014Mutations in the -myosin heavy-chain (MyHC) gene cause hypertrophic (HCM) and dilate...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
Hypertrophic cardiomyopathy occurs as an autosomal domi-nant familial disorder or as a sporadic dise...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...
Striated muscle myosin heavy chain is a molecular motor protein that converts chemical energy into m...