Hyperinsulinemia in African-American Children Decreased Insulin Clearance and Increased Insulin Secretion and Its Relationship to Insulin Sensitivity

children. This study investigated 1) whether AA/AW dif-ferences in insulinemia are associated with differences in insulin clearance; 2) whether dietary patterns, mainly carbohydrate and fat intake, play a role; and 3) whether the quantitative relationship between insulin sensitivity and secretion is similar between AA and AW children. Forty-four prepubertal children (22 AA and 22 AW) with comparable body composition and visceral adiposity were studied. All underwent a 3-h hyperinsulinemic (40 mU m2 min1)-euglycemic clamp to calculate insulin sensi-tivity and insulin clearance and a 2-h hyperglycemic clamp (12.5 mmol/l) to assess first- and second-phase insulin responses. Twenty-four–hour food recalls were analyzed for macronutrient intake. Insulin clearance (19.5 0.7 vs. 22.9 1.1 ml min1 kg1 fat-free mass [FFM]; P 0.011