Occupation and bladder cancer in a population-based caseecontrol study in Northern New England

Objectives We used data from a large, population-based caseecontrol study inMaine, NewHampshire, and Vermont to examine relationships between occupation, industry and bladder cancer risk. Methods Lifetime occupational histories were obtained by personal interview from 1158 patients newly diagnosed with urothelial carcinoma of the bladder in 2001e2004, and from 1402 population controls. Unconditional logistic regression was used to calculate ORs and 95 % CIs, adjusted for demographic factors, smoking and employment in other high-risk occupations. Results Male precision metalworkers and metalworking/ plasticworking machine operators had significantly elevated risks and significant trends in risk with duration of employment (precision metalworkers: OR 2.2, 95 % CI 1.4 to 3.4, ptrend0.0065; metalworking/plasticworkin