Protein kinase C- inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells

kinase C- inhibits the repair of oxidative phosphorylation after S-(1,2-dichlorovinyl)-L-cysteine injury in renal cells. Am J Physiol Renal Physiol 287: F64–F73, 2004. First published March 2, 2004; 10.1152/ajprenal.00216.2003.—Previously, we showed that physio-logical functions of renal proximal tubular cells (RPTC) do not recover following S-(1,2-dichlorovinyl)-L-cysteine (DCVC)-induced injury. This study investigated the role of protein kinase C- (PKC-) in the lack of repair of mitochondrial function in DCVC-injured RPTC. After DCVC exposure, basal oxygen consumption (QO2), uncoupled QO2, oligomycin-sensitive QO2, F1F0-ATPase activity, an