Add to ORKGThe CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-guided DNA targeting platform. It has been widely used for genome editing and transcriptome modulation, and has shown great promise in correcting mutations in human genetic diseases. Off-target effects are a critical issue for all of these applications. Here we review the current status on the target specificity of the CRISPR-Cas9 system
CRISPR/Cas9 genome editing technology is the frontier of life science research. They have been used ...
Abstract Genome editing allows for the precise manipulation of DNA sequences in a cell making this t...
CRISPR (clustered regulatory interspaced short palindromic repeats) is a bacterial adaptive immune s...
The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-...
The specificity of RNA-guided nucleases has gathered considerable interest as they become broadly ap...
The specificity of RNA-guided nucleases has gathered considerable interest as they become broadly ap...
While human gene therapy has gained significant attention for its therapeutic promise, CRISPR/Cas9 t...
CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functional...
The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 (CRISPR -associated nucle...
<p>Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRI...
Gene therapy is based on the principle of the genetic manipulation of DNA or RNA for treating and pr...
CRISPR-Cas9 is a revolutionary genome-editing tool. Understanding how Cas9 recognizes DNA and how to...
Several studies have introduced CRISPR-Cas9 as a prominent genome-editing technology. CRISPR was fir...
Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated...
CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) are the segments of prokaryotic ...
CRISPR/Cas9 genome editing technology is the frontier of life science research. They have been used ...
Abstract Genome editing allows for the precise manipulation of DNA sequences in a cell making this t...
CRISPR (clustered regulatory interspaced short palindromic repeats) is a bacterial adaptive immune s...
The CRISPR-Cas9 system, naturally a defense mechanism in prokaryotes, has been repurposed as an RNA-...
The specificity of RNA-guided nucleases has gathered considerable interest as they become broadly ap...
The specificity of RNA-guided nucleases has gathered considerable interest as they become broadly ap...
While human gene therapy has gained significant attention for its therapeutic promise, CRISPR/Cas9 t...
CRISPR/Cas9 is a versatile genome-editing technology that is widely used for studying the functional...
The CRISPR (clustered regularly interspaced short palindromic repeat)/Cas9 (CRISPR -associated nucle...
<p>Since the discovery of CRISPR-Cas (Clustered Regularly Interspaced Short Palindromic Repeats, CRI...
Gene therapy is based on the principle of the genetic manipulation of DNA or RNA for treating and pr...
CRISPR-Cas9 is a revolutionary genome-editing tool. Understanding how Cas9 recognizes DNA and how to...
Several studies have introduced CRISPR-Cas9 as a prominent genome-editing technology. CRISPR was fir...
Targeted genome editing technology has been widely used in biomedical studies. The CRISPR-associated...
CRISPRs (Clustered Regularly Interspaced Short Palindromic Repeats) are the segments of prokaryotic ...
CRISPR/Cas9 genome editing technology is the frontier of life science research. They have been used ...
Abstract Genome editing allows for the precise manipulation of DNA sequences in a cell making this t...
CRISPR (clustered regulatory interspaced short palindromic repeats) is a bacterial adaptive immune s...