LYMPHOID NEOPLASIA Conditional TPM3-ALK and NPM-ALK transgenic mice develop reversible ALK-positive early B-cell lymphoma/leukemia

muscular tropomyosin 3-anaplastic lym-phoma kinase) are oncogenic tyrosine kinases implicated in the pathogenesis of human ALK-positive lymphoma. We re-port here the development of novel condi-tional mouse models for ALK-induced lymphomagenesis, with the use of the tetracycline regulatory system under the control of the ESR enhancer/promoter. The expression of either oncogene re-sulted in the arrest of the differentiation of early B cells and lymphomagenesis. We also observed the development of skin keratoacanthoma lesions, probably because of aberrant ALK expression i