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The aim of this study was to assess the effects of artificial unloading induced by hindlimb suspension on the trabecular bone in tibiae. Twenty four 12-week-old Sprague-Dawley rats were assigned to 3 groups, namely, the control group (CON, n = 8), the hindlimb-suspended group (HLS, n = 8) and HLS with partial vibration group (HLSPV, n = 8). After 4 weeks, compared with CON group, HLS group had significantly greater decreases on BMD, BV/TV, Tb.N, Conn.Dn and increase on Tb.Sp (p < 0.05). However, there were no significant differences in BMD and the other micro structural parameters of tibial trabecular bones between CON and HLSPV (p> 0.05). These results implied that partial vibration might inhibit the bone loss induced by hindlimb suspension. Furthermore, we could expect to apply partial vibration system in space environment