K.: Cardiac nucleotides and derivatives in acute and chronic ventricular failure of the dog heart. Circulation Res. 9: 618

AS A CONSEQUENCE of our observationson the inotropic effects of nueleosides on acute ventricular failure in the isolated dog heart,1 we have investigated myocardial pu-rine and pyrimidine derivatives, including nucleotide components, in similar types of cardiac failure. Although other workers have examined high-energy phosphate compounds in cardiac failure, no total pattern studies have been made, and the reported findings relative to adenine nucleotides are incon-sistent.2"5 "With the recent development of analytical techniques allowing reliable quanti-tative separation and measure of tissue nu-cleotides6 and their derivatives, it has become possible to establish definitively their distribu-tion in myocardium. The experimental preparation chosen pro-vided both a failing and a nonfailing ventricle in a single heart, permitting the unique ad-vantage of the use of one ventricle as a bio-chemical control for the other. We had pre-viously shown that unilateral left ventricular failure could be produced without involving the right ventricle,7 by a heniodynamic stress rather than the use of drugs, which compli-cated the results of other workers.8'9 The type of failure induced in the present experi-ments is defined as ventricular insufficiency or inadequacy of response to increased work loads, resulting from (1) acute and (2) chronic heniodynamic overloading of the left ventricle