Management of Residual Mass in Advanced Seminoma: Results and Recommendations From the Memorial Sloan-Kettering Cancer Center

Purpose: Guidelines for management of postchemo-therapy residual mass in patients with advanced semi-noma remain controversial. We sought to characterize independent prognostic factors) for persistence of tumor to identify patients with a high risk of residual carci-noma. Patients and Methods: One hundred four patients with advanced seminoma were assessed. All had achieved a complete response or partial response with normal markers to induction cisplatin-based chemother-apy and had radiographs available for review. Selected prechemotherapy and postchemotherapy characteristics were compared for patients who had either germ cell tumor histology at surgery or relapsed at the assessed site (defined as site failure) versus those who had onl