Copyright © 1991, American Society for Microbiology A 220-Kilodalton Glycoprotein in Yeast Extract Inhibits Staphylococcus aureus Adherence to

A 220-kDa glycoprotein from yeast extract causes a twofold decrease in S. aureus adherence to human endothelial cells in vitro. Medium constituents can have a significant effect on bacterial adherence interactions. During the course of studies investigating mechanisms of Staphylococcus aureus adherence to human endothelial cells, we noted differences in adherence which appeared to relate to the type of growth medium used. This report summarizes our investigation of the factors responsible for this effect. The infection assay used in this study has been previously described (4, 8). S. aureus Wb (4, 8) was grown either i