Oxidative/nitrosative stress in psychiatric disorders: are we there yet

While oxidative stress has a clear role in neurodegenera-tive diseases, its involvement in psychiatric disorders is only beginning to be understood. Evidence for oxidative stress and redox dysregulation in psychiatric disorders is rapidly mounting, and preclinical data are increas-ingly suggesting oxidative stress can affect brain circuits involved in schizophrenia, yielding altered behaviors. This issue of Schizophrenia Bulletin covers some recent developments in human and animal studies highlight-ing the possibility of oxidative and nitrosative stress contributing to abnormal behaviors. Hayes et al1 pres-ent data of inflammation-related measures in patients, at-risk subjects, and healthy controls revealing altered cytokines in the cerebrospinal fluid (CSF) of patients and at-risk mental state subjects. Fournier et al2 provid