Clinical Investigation

ap-hop-paris.fr The predictive value of plasma renin measurement depends on both the quality of the classification of the investigated events and that of plasma renin measurement. Although all-cause death may be the most robust event and potentially devoid of risk of error, in most observational studies and trials it usually fails to give clear results simply because of inadequate statistical power. The term plasma renin concentration (PRC) is often confused with the term plasma renin activ-ity (PRA). PRC is determined by an immunoradio-metric assay. This assay uses two monoclonal antibodies and measures the number of active renin molecules independently of their enzymati