Improvement of glycemic status by insulin is associated with profound changes in amino acid metabolism in type 1 diabetes. In contrast, a dissociation of insulin effect on glucose and amino acid metabolism has been re-ported in type 2 diabetes. Type 2 diabetic patients are reported to have reduced muscle oxidative enzymes and VO2max. We investigated the effect of 11 days of inten-sive insulin treatment (T2D) on whole-body amino acid kinetics, muscle protein synthesis rates, and mus-cle functions in eight type 2 diabetic subjects after withdrawing all treatments for 2 weeks (T2D) and compared the results with those of weight-matched lean control subjects using stable isotopes of the amino acids. Whole-body leucine, phenylalanine and tyrosine...
The ability to maintain skeletal muscle mass appears to be impaired in insulin resistant conditions ...
Systemic insulin administration causes hypoaminoacidemia by inhibiting protein degradation, which ma...
Transmembrane transport of neutral amino acids in skeletal muscle is mediated by at least four diffe...
Deficiency of insulin results in a net loss of lean body mass and wasting of muscle. The...
Protein ingestion stimulates muscle protein synthesis and improves net muscle protein balance. Insul...
To evaluate the anabolic effects of hyperinsulinemia and hyperaminoacidemia on amino acid (and prote...
The rate of whole body protein turnover was measured in uncontrolled diabetic patients by c15N ] gly...
To determine the in vivo effect of amino acids (AAs) alone or in combination with insulin on splanch...
It has long been recognized that diabetes mellitus is characterized by alterations in amino acid met...
Although insulin resistance of glucose and fat metabolism in type 2 diabetes mellitus (T2DM) is firm...
Despite being an anabolic hormone in skeletal muscle, insulin's anticatabolic mechanism in humans re...
AbstractSeveral defects in response to insulin have been described in vivo and in vitro in type 2 di...
In patients with non-insulin-dependent diabetes mellitus (NIDDM) and matched control subjects we exa...
The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions,...
To elucidate the mechanism of insulin's anticatabolic effect in humans, protein dynamics were e...
The ability to maintain skeletal muscle mass appears to be impaired in insulin resistant conditions ...
Systemic insulin administration causes hypoaminoacidemia by inhibiting protein degradation, which ma...
Transmembrane transport of neutral amino acids in skeletal muscle is mediated by at least four diffe...
Deficiency of insulin results in a net loss of lean body mass and wasting of muscle. The...
Protein ingestion stimulates muscle protein synthesis and improves net muscle protein balance. Insul...
To evaluate the anabolic effects of hyperinsulinemia and hyperaminoacidemia on amino acid (and prote...
The rate of whole body protein turnover was measured in uncontrolled diabetic patients by c15N ] gly...
To determine the in vivo effect of amino acids (AAs) alone or in combination with insulin on splanch...
It has long been recognized that diabetes mellitus is characterized by alterations in amino acid met...
Although insulin resistance of glucose and fat metabolism in type 2 diabetes mellitus (T2DM) is firm...
Despite being an anabolic hormone in skeletal muscle, insulin's anticatabolic mechanism in humans re...
AbstractSeveral defects in response to insulin have been described in vivo and in vitro in type 2 di...
In patients with non-insulin-dependent diabetes mellitus (NIDDM) and matched control subjects we exa...
The ability to maintain skeletal muscle mass appears to be impaired in insulin-resistant conditions,...
To elucidate the mechanism of insulin's anticatabolic effect in humans, protein dynamics were e...
The ability to maintain skeletal muscle mass appears to be impaired in insulin resistant conditions ...
Systemic insulin administration causes hypoaminoacidemia by inhibiting protein degradation, which ma...
Transmembrane transport of neutral amino acids in skeletal muscle is mediated by at least four diffe...
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