EFFECT OF TWO FORMULATIONS OF BENZIMIDAZOLE CARBAMATES ON THE VIABILITY OF CYSTS OF ECHINOCOCCUS GRANULOSUS IN VIVO

benzimidazole carbamate drugs, mebendazole, albendazole and ricobendazole, were compared by analyzing their in vivo activity against Echinococcus granulosus cysts in a mouse model. Polyvinylpyrrolidone was used for the elaboration of drug solutions and these formulations manifested better results in terms of reduction of number of viable hydatid cysts in mice than the reference drug suspensions. The effect was more prominent on mebendazole-treated mice, at doses of 25-50 mg/kg. There was a correlation between E D 5 0 and pharmacokinetical parameters of A U C 0 and C M A X, showing that a significant improvement on solubility affects the in vivo activity of these drugs