Protein expression regulation under oxidative stress. Mol. Cell. Proteomics 10:M111.009217. http://dx .doi.org/10.1074/mcp.M111.009217

Oxidative stress is known to affect both translation and protein turnover, but very few large scale studies describe protein expression under stress. We measure protein concentrations in Saccharomyces cerevisiae over the course of 2 h in response to a mild oxidative stress in-duced by diamide, providing detailed time-resolved infor-mation for 815 proteins, with additional data for another 1,100 proteins. For the majority of proteins, we discover major differences between the global transcript and pro-tein response. AlthoughmRNA levels often return to base-line 1 h after treatment, protein concentrations continue to change. Integrating our data with features of transla-tion and protein degradation, we are able to predict ex-pression patterns for 41 % of the proteins in the core data set. Predictive features include, among others, targetin