PHARMACOKINETICS AND METABOLISM OF FENBENDAZOLE IN HEALTHY DOGS

Abstract: The aim of the study has been evaluation of the pharmacokinetics of fenbendazole molecule, with the experimental protocol for drug testing, using a test (Anipratel) dose of 214.9 mg, compared with a reference (Cestal) dose of 200 mg (table 1). The researches was made on 10 healthy dogs (n=10) from Romanian shepherd bred. All the dogs received a single oral tablet with fenbendazol, in two phases, one time with product contain the test dose (200 mg), and after 14 days, a second administration using a test product in dose of 214.9 mg. Before and after each administration of drugs, were collected blood samples at various time intervals: 0.0, 0.5. 1.0, 1.5, 2.0, 4.0, 8.0, 12.0, 24.0, 36.0, and 48.0 hours. The pharmacokinetics of fenbendazole was characterized by reaching the maximum plasmatic concentration after oral administration in 1-2 hours with the limits between 104.7 and 8.2 ng/ml. The half-time values have the variation between 2.77 and 13.81 hours according with the active ingredient dose. The kidney clearance of fenbendazole revealed value between 101.98 l/hors and 395.32 l/hours, those values being characteristic for the turnover and elimination of fenbendazole from the animal body. General and statistic analyze of followed pharmacological parameters revel the possibility that the fenbendazole from this two products can be different metabolized because of the different used dose