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Sponsorships or competing interests that may be relevant to content are dis-closed at the end of this article. Objective. As skin cancer incidence increases, research has focused on novel chemopreventive agents that inhibit tumor formation. In prior experimentation, curcumin, a naturally occurring food substance and anticarcinogenic agent, inhib-ited cutaneous squamous cell carcinoma xenograft growth. We hypothesize curcumin will inhibit UVB radiation–induced skin cancer growth in mice, approximating a human chemo-preventive model. Study Design. Randomized experimental animal and labora-tory study