© 2009 Atlas of Genetics and Cytogenetics in Oncology and Haematology Identity

Viewer, genes flanking BCL2L11 in plus strand direction are: ACOXL 2q13 (acyl-Coenzyme A oxidase-like); PAFAH1P2 2q13 (platelet-activating factor acetylhydrolase, isoform Ib, pseudogene 2). Note: BCL2L11/BIM is a BH3-only protein from the Bcl-2 family. Bcl-2 family members are the main regulators of programmed cell death via the mitochondrial (intrinsic) apoptotic pathway. Interactions between pro- and anti-apoptotic proteins of the Bcl-2 family decide the fate of cells after a stress signals. BH3-only proteins are activated in response to cellular stresses such as DNA damage. BCL2L11/BIM is one of the most potent BH3-only proteins, shown to mediate apoptosis in response to stimuli such as cytokine deprivation, deregulated calcium flux an