Neural stem cells

MicroRNA (miRNA) expression profiles were generated from prostate epithelial sub-populations enriched from patient-derived benign prostatic hyperplasia (n = 5), Gleason 7 treatment-naive prostate cancer (PCa) (n = 5), and castration-resistant PCa (CRPC) (n = 3). Microarray expression was validated in an independent patient cohort (n = 10). Principal component analysis showed that miRNA expression is clustered by epithelial cell phenotype, regardless of pathologic status.We also discovered concordance between the miRNA expression profiles of unfractionated epithelial cells from CRPCs, human embryonic stem cells (SCs), and prostate epithelial SCs (both benign and malignant). Patient summary: We report microRNA (miRNA) expression profiles of epithelial cell * Corresponding author E-mail address: n.j.maitfractions from the human prostate, including stem cells. miR-548c-3p was revealed as a functional biomarker for prostate cancer progression. The evaluation ofmiR-548c-3p in a larger patient cohort should yield information on its clinical usefulness