Schizophrenia in TranSlaTion Modeling Schizophrenia Using induced pluripotent Stem cell–Derived and

although schizophrenia affects a number of brain regions and produces a range of clinical symptoms, we believe its origins lie at the level of single neurons and simple networks. owing to this, as well as to its high degree of heritability, we hypothesize that schizophrenia is amenable to cell-based studies in vitro. Using induced pluripotent stem cell–derived neurons and/or fibroblast-induced neurons, a limitless quan-tity of live human neurons can now be generated from patient skin biopsies. We predict that cell-based studies will ulti-mately contribute to our understanding of the molecular and cellular underpinnings of this debilitating disorder. Key words: neurons/stem cells/genetics reprogramming of hipScs From Fibroblasts The ability to reprogram patient somatic cells into human-induced pluripotent stem cells (hiPSCs) pro