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Sponsorships or competing interests that may be relevant to content are dis-closed at the end of this article. Objective. We are designing an implantable neuroprosthesis for the treatment of unilateral facial paralysis. The envi-sioned biomimetic device paces artificial blinks in the paretic eyelid when activity in the healthy orbicularis oculi (orbicu-laris) muscle is detected. The present article focuses on electromyography (EMG)–based eyeblink detection. Study Design. A pilot clinical study was performed in healthy volunteers who were intended to represent individuals with facial paralysis. Spontaneous eyeblinks were detected by a surface EMG recording. Blink detection accuracy was tested at rest and during voluntary smiling and chewing. Setting. Fifteen participants were asked to wear surfac