Overview The original, classic Price-Jones

studies1,2 on the het-erogeneity of red blood cell diameters have paved the way in establishing red cell anisocytosis as a means of evaluating red cell morphology in health and disease. Price-Jones quantifies anisocytosis as a coefficient of variation (CV) of red blood cell size in a Price-Jones curve, which serves to determine the presence and degree of red cell volume heterogeneity. Heterogeneity generally has been identified by qualitative inspection of peripheral blood film (PBF). However, because of the technical difficulty in measuring red cell variability from the PBF, recently designed automated particle counters have allowed rapid and precise quantitation of volume heterogeneity.3,4 Measured as a CV, red blood cell distri-bution width (RDW) is now an integral part of automate