Rill Suppressed Expression in Goat Antiserum to Mammary Tumor Virus (MuMTV) Female Mice Treated Neonatally With

mice with the globulin fraction of goat antiserum to murine mammary tumor virus (MuMTV) successfully suppressed MuMTV expression In the milk of some of the treated mice throughout nine successive lactations. No mammary tumors developed In the MuMTV-suppressed mice during the first 9 months, whereas all untreated R3 female breeders expressed MuMTV In the milk of the third lactation, and all developed tumors before 9 months of age (mode and median: 189 days).-J Natl Cancer Inst 61: 437-439, 1978. Spontaneously occurring oncornavirus-induced tu-mors are unique among malignant lesions in that they develop on the background of a preexisting humoral immune response, as well as cell-mediated immune response, directed against some of the virus-associated antigens expressed on the tumor cells (1). The prospec