Cytogenetic and Histologic Correlations in Malignant Lymphoma

Although a number of studies have indicated correlations between histologic subtypes of tumors and certain nonran-dom chromosome changes. cytogenetic studies of lym-phoma are in an early stage compared to those of leukemia. No comprehensive analysis of available data has so far been attempted in the literature either. Here we present an analysis of chromosome changes and their correlation with subtypes of lymphoma studied by conventional histol-ogy and cell surface markers. as observed in two sets of data: (1) a group of 65 karyotypically abnormal tumors sequentially ascertained and studied by us during the period January 1. 1 984 to April 30, 1 985. and (2) a larger data set derived by combining our data with those from two published series from the University of Minnesota that are comparable to our data. These combined data, whic