Purine compounds, such as caffeine, have many health-promoting properties and have proven to be beneficial in treating a number of different conditions. Theacrine, a purine alkaloid structurally similar to caffeine and abundantly present in Camellia kucha, has recently become of interest as a potential therapeutic compound. In the present study, theacrine was tested using a rodent behavioral model to investigate the effects of the drug on locomotor activity. Long Evans rats were injected with theacrine (24 or 48 mg/kg, i.p.) and activity levels were measured. Results showed that the highest dose of theacrine (48 mg/kg, i.p.) significantly increased locomotor activity compared to control animals and activity remained elevated throughout the ...
AbstractAn adenosine antagonist, 8-(3-chlorostyryl)caffeine (CSC), was shown previously to be 520-fo...
The acute motor response to caffeine was studied in rats repeatedly treated with vehicle or the dopa...
Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of ab...
1. The locomotor stimulatory effects induced by caffeine (1,3, 7-trimethylxanthine) in rodents have ...
Recent data indicate that cocaine locomotor responses may be influenced by dopamine (DA) neurotransm...
Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical a...
Preclinical evidence indicates an important role of adenosine (A)2A receptors in drug addiction whil...
Using a Digiscan Actimeter, many previous studies have shown that low dose caffeine (6.25- 25 mg/kg)...
Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical a...
The effects of caffeine, an antagonist of adenosine A(1) and A(2A) receptors, are significantly infl...
Caffeine is a methylxanthine that acts as a nonselective adenosine antagonist, binding to adenosine ...
Neuropeptide S (NPS) is the endogenous ligand of a G-protein-coupled receptor named as NPSR. Behavio...
Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transport...
RATIONALE: Dopamine transmission acting at either the D(1) or D(2) receptor level is known to inf...
Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transport...
AbstractAn adenosine antagonist, 8-(3-chlorostyryl)caffeine (CSC), was shown previously to be 520-fo...
The acute motor response to caffeine was studied in rats repeatedly treated with vehicle or the dopa...
Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of ab...
1. The locomotor stimulatory effects induced by caffeine (1,3, 7-trimethylxanthine) in rodents have ...
Recent data indicate that cocaine locomotor responses may be influenced by dopamine (DA) neurotransm...
Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical a...
Preclinical evidence indicates an important role of adenosine (A)2A receptors in drug addiction whil...
Using a Digiscan Actimeter, many previous studies have shown that low dose caffeine (6.25- 25 mg/kg)...
Behavioral activation is regulated by dopamine (DA) in striatal areas. At low doses, while typical a...
The effects of caffeine, an antagonist of adenosine A(1) and A(2A) receptors, are significantly infl...
Caffeine is a methylxanthine that acts as a nonselective adenosine antagonist, binding to adenosine ...
Neuropeptide S (NPS) is the endogenous ligand of a G-protein-coupled receptor named as NPSR. Behavio...
Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transport...
RATIONALE: Dopamine transmission acting at either the D(1) or D(2) receptor level is known to inf...
Cocaine increases the level of endogenous dopamine (DA) in the striatum by blocking the DA transport...
AbstractAn adenosine antagonist, 8-(3-chlorostyryl)caffeine (CSC), was shown previously to be 520-fo...
The acute motor response to caffeine was studied in rats repeatedly treated with vehicle or the dopa...
Adenosine, acting on A(2A) adenosine receptors, regulates addictive processes induced by drugs of ab...