The Relationship Between Lymphocyte Responsiveness to Lymphokines and S~sceptibility to Viral Infection in

ii Two inbred strains of Syrian hamster have been shown to display genetically determined differences in resistance to infections witn the arenavir~s, pichinde vir~s (PV). After intraperitoneal injection, the vir~s grows to higher titres in the spleens of, the susceptible strain, MHA, than in the spleens of the.resistant·strain, LSH. prelimi~ary s~udies examining the basis of suscept~bility demonstrated that resistance o~ susceptibility to the vir~s did not lie in an inherent difference in 'target cells to become inf~cted, b~t suggested that there was a quantitative difference in target cells between the two st~ains of hamster. The following experiments were cond~cted in attempts t