LITERATURE REVIEW Thyroid gland management in total laryngectomy: Meta-analysis and surgical recommendations

OBJECTIVES: 1) Review the incidence of thyroid gland inva-sion by squamous cell laryngeal carcinoma reported in the litera-ture. 2) Assess the association between thyroid gland invasion and anatomical characteristics of the laryngeal tumor. DATA SOURCES: MEDLINE (1967-2007) and EMBASE (1980-2007). These databases were supplemented with 61 patients from McGill University who underwent total laryngectomy with hemi- or total thyroidectomy from 2001-2006. REVIEW METHODS: Systematic review for series of laryn-geal carcinoma that commented on thyroid gland invasion ac-cording to tumor subsite and pathological characteristics. Total laryngectomy specimens for primary laryngeal squamous cell carcinoma with concomitant thyroid resection were included in the analysis. RESULTS: In total, eight series (n 399) were included in th