Intracellular Scaling Mechanisms

Organelle function is often directly related to organelle size. However, it is not necessarily absolute size but the organelle-to-cell-size ratio that is critical. Larger cells generally have increased metabolic demands, must segregate DNA over larger distances, and require larger cytokinetic rings to divide. Thus, organelles often must scale to the size of the cell. The need for scaling is particularly acute during early development during which cell size can change rapidly. Here, we highlight scaling mechanisms for cellular structures as diverse as centro-somes, nuclei, and themitotic spindle, and distinguish them frommore general mechanisms of size control. In some cases, scaling is a consequence of the underlying mechanism of organelle size control. In others, size-control mechanisms are not obviously related to cell size, implying that scaling results indirectly from cell-size-dependent regulation of size-control mechanisms. A cell is a highly organized unit in whichfunctions are compartmentalized into spe-cific organelles. Each cellular organelle carries out a distinct function, which is not only related to its molecular composition but, in many cas