' Correspondence and reprints

L'irnmobilisation d'une sequence d'oligonucleotides par copolymerisation avec un monomere pyrrole sur une surface de platine a ete realisee sur une microbalance a quartz. L'efficacite de ce biocapteur a et6 etudiee en presence de differents oligonucleotides sondes. Les reponses de I'hybridation et de l'adsorption ont ete mesurees in-situ par le changement de frequence de la microbalance a quartz. Mots-clks: oligonucleotides, copolymerisation, microbalance a quartz, biocapteur, hybridation. The immobilization of an oligonucleotide via a copolymerisation with a pyrrole monomer onto a Pt surface has been realized on a quartz crystal microbalance (QCM). The efficiency of this biosensor has been evaluated through the hybridization with differents targets. Hybridization and adsorption responses were monitored in-situ by QCM frequency change. Key words: oligonucleotides, copolymerisation, quartz crystal microbalance, biosensor, hybridization. Detection of hybridization on copolymer-DNA by QCM 151