Pre-Surgical Mood Disorders Associated to Worse Post-Surgical Seizure Outcome in Patients with Refractory Temporal Lobe Epilepsy and Mesial Temporal Sclerosis

J Epilepsy
Clin Neurophysiol
Gerardo Maria
Araújo Filhoa
Francinaldo Lobato Gomesa
Lenon Mazettoa
Murilo Martinez Marinhoa
Igor Melo Tavaresa
Luís Otávio
Sales Ferreira Cabocloa
Elza Márcia
Targas Yacubiana
Ricardo Silva Centenoa

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Publication date

January 2012

DOI

10.1590/s1676-26492012000100006

ISSN

1676-2649

Abstract

Objectives: This study aims at verifying the impact of pre-surgical PD on seizure outcome in patients with refractory temporal lobe epilepsy and mesial temporal sclerosis (TLE-MTS). Methods: After previous consent, retrospective data from 115 surgically treated (corticoamygdalohyppocampectomy) TLE-MTS patients (65 females; 56.5%) were analyzed. Psychiatric evaluations were performed through DSM-IV criteria. Engel IA was established as a favorable prognosis. Results: Forty-five patients (41.6%) were classified as Engel IA, while 47 (40.8%) presented pre-surgical PD. Depression (OR=5.11; p=0.004) appeared as a risk factor associated to a non-favorable seizure outcome. Conclusion: In patients with refractory TLE-MTS, the presence of depression...